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human normal lung epithelial beas 2b cells  (ATCC)


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    ATCC human normal lung epithelial beas 2b cells
    Acidic microenvironment condition screening and LAMC2 expression validation. (A) Comparison of relative LAMC2 expression levels in different cell lines <t>(BEAS-2B,</t> HCC827, and A549), showing a significantly higher expression in HCC827 and A549 cells compared to BEAS-2B cells. (B) Changes in LAMC2 expression in HCC827 and A549 cells under different lactate (LA) concentrations (10, 20, and 30 mM), showing significant increases in LAMC2 expression at 20 and 30 mM concentrations. (C) Changes in LAMC2 expression over time (0, 6, 12, and 24 h) in HCC827 and A549 cells treated with 20 mM LA, showing a significant increase in expression with longer treatment times. (D) Changes in LAMC2 expression under different acidic environment conditions (high LA, hydrochloric-acid-induced acidosis, and control groups) in HCC827 and A549 cells, with a significantly higher expression in the high LA and hydrochloric-acid-induced acidosis groups. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
    Human Normal Lung Epithelial Beas 2b Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 3788 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    1) Product Images from "Acidic microenvironment-induced LAMC2 expression promotes proliferation, migration, and pathway regulation in non-small cell lung cancer cells"

    Article Title: Acidic microenvironment-induced LAMC2 expression promotes proliferation, migration, and pathway regulation in non-small cell lung cancer cells

    Journal: Frontiers in Oncology

    doi: 10.3389/fonc.2026.1747868

    Acidic microenvironment condition screening and LAMC2 expression validation. (A) Comparison of relative LAMC2 expression levels in different cell lines (BEAS-2B, HCC827, and A549), showing a significantly higher expression in HCC827 and A549 cells compared to BEAS-2B cells. (B) Changes in LAMC2 expression in HCC827 and A549 cells under different lactate (LA) concentrations (10, 20, and 30 mM), showing significant increases in LAMC2 expression at 20 and 30 mM concentrations. (C) Changes in LAMC2 expression over time (0, 6, 12, and 24 h) in HCC827 and A549 cells treated with 20 mM LA, showing a significant increase in expression with longer treatment times. (D) Changes in LAMC2 expression under different acidic environment conditions (high LA, hydrochloric-acid-induced acidosis, and control groups) in HCC827 and A549 cells, with a significantly higher expression in the high LA and hydrochloric-acid-induced acidosis groups. ** p < 0.01, *** p < 0.001, **** p < 0.0001.
    Figure Legend Snippet: Acidic microenvironment condition screening and LAMC2 expression validation. (A) Comparison of relative LAMC2 expression levels in different cell lines (BEAS-2B, HCC827, and A549), showing a significantly higher expression in HCC827 and A549 cells compared to BEAS-2B cells. (B) Changes in LAMC2 expression in HCC827 and A549 cells under different lactate (LA) concentrations (10, 20, and 30 mM), showing significant increases in LAMC2 expression at 20 and 30 mM concentrations. (C) Changes in LAMC2 expression over time (0, 6, 12, and 24 h) in HCC827 and A549 cells treated with 20 mM LA, showing a significant increase in expression with longer treatment times. (D) Changes in LAMC2 expression under different acidic environment conditions (high LA, hydrochloric-acid-induced acidosis, and control groups) in HCC827 and A549 cells, with a significantly higher expression in the high LA and hydrochloric-acid-induced acidosis groups. ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Techniques Used: Expressing, Biomarker Discovery, Comparison, Control



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    Acidic microenvironment condition screening and LAMC2 expression validation. (A) Comparison of relative LAMC2 expression levels in different cell lines (BEAS-2B, HCC827, and A549), showing a significantly higher expression in HCC827 and A549 cells compared to BEAS-2B cells. (B) Changes in LAMC2 expression in HCC827 and A549 cells under different lactate (LA) concentrations (10, 20, and 30 mM), showing significant increases in LAMC2 expression at 20 and 30 mM concentrations. (C) Changes in LAMC2 expression over time (0, 6, 12, and 24 h) in HCC827 and A549 cells treated with 20 mM LA, showing a significant increase in expression with longer treatment times. (D) Changes in LAMC2 expression under different acidic environment conditions (high LA, hydrochloric-acid-induced acidosis, and control groups) in HCC827 and A549 cells, with a significantly higher expression in the high LA and hydrochloric-acid-induced acidosis groups. ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Journal: Frontiers in Oncology

    Article Title: Acidic microenvironment-induced LAMC2 expression promotes proliferation, migration, and pathway regulation in non-small cell lung cancer cells

    doi: 10.3389/fonc.2026.1747868

    Figure Lengend Snippet: Acidic microenvironment condition screening and LAMC2 expression validation. (A) Comparison of relative LAMC2 expression levels in different cell lines (BEAS-2B, HCC827, and A549), showing a significantly higher expression in HCC827 and A549 cells compared to BEAS-2B cells. (B) Changes in LAMC2 expression in HCC827 and A549 cells under different lactate (LA) concentrations (10, 20, and 30 mM), showing significant increases in LAMC2 expression at 20 and 30 mM concentrations. (C) Changes in LAMC2 expression over time (0, 6, 12, and 24 h) in HCC827 and A549 cells treated with 20 mM LA, showing a significant increase in expression with longer treatment times. (D) Changes in LAMC2 expression under different acidic environment conditions (high LA, hydrochloric-acid-induced acidosis, and control groups) in HCC827 and A549 cells, with a significantly higher expression in the high LA and hydrochloric-acid-induced acidosis groups. ** p < 0.01, *** p < 0.001, **** p < 0.0001.

    Article Snippet: Human normal lung epithelial BEAS-2B cells (ATCC ® CRL-9609TM) and lung cancer cell lines A549 (Procell, CL-0016, lung adenocarcinoma) and HCC827 (Procell, CL-0094, lung adenocarcinoma) were obtained from the indicated suppliers.

    Techniques: Expressing, Biomarker Discovery, Comparison, Control